When fishing slows, here is the honest sequence.
Move first if you need to. If you have fished a run for a reasonable stretch of time with zero contact, not refusals, not near-misses, just nothing, trust that signal. The fish may not be there. Work downstream or upstream to a different feature. The most experienced anglers on a river spend as much time reading and moving as they do casting.
Adjust presentation before you change flies. If you are getting some contact but inconsistent results, or if your indicator is moving at a speed that does not match the water around it, fix the drift first. This usually means correcting depth, improving your mend, or repositioning to get a better angle on the run. These adjustments take two or three minutes and can completely turn a run around.
Then, and only then, look at the fly. When you reach the point where location is right, the drift is clean and natural, fish are in the zone, and you are still getting nothing or consistent refusals, it is time to look at the pattern. Ask whether the size makes sense. Ask whether the profile is reasonable for what is in the water. Ask whether a color adjustment might help. These are legitimate questions, but they are only useful after the first two pillars are solid.
There are days when the fly genuinely is the problem. If a major hatch is on and fish are keyed tightly to one specific insect, matching the general size and shape of that insect becomes important. Highly pressured fish on clear tailwaters can also become selective in ways that require more precise patterns. Those situations are real, but they are not the default. They are the exception.
Most days, on most rivers, a reasonable nymph in the right zone on a clean drift is enough. The angler who learns to diagnose location and presentation honestly will outfish the angler cycling through flies on nine out of ten days.
The framework is simple. Check location. Check presentation. Then check the fly. Run the sequence in that order every time fishing slows, and you will spend far less time frustrated at the fly box and far more time with a bent rod.